Author(s):
Short-chain fatty acids (SCFAs) are key modulators of host health, intricately linking the gut microbiome with various physiological systems. They regulate gut-brain axis communication, impacting gut barrier, inflammation, and neuroinflammation. SCFAs are crucial in host metabolism, influencing energy homeostasis, glucose tolerance, and insulin sensitivity, relevant for metabolic syndrome and diabetes. They also modulate immune responses, affecting autoimmune diseases, and play a dual role in cancer progression. Furthermore, SCFAs are implicated in COVID-19 severity, cardiovascular health, and neurological disorders, influencing brain function and neurodegeneration. Their epigenetic mechanisms underscore their broad therapeutic potential across metabolic, immune, and neurological conditions.
