Nigerian Society of Biochemistry and Molecular Biology

Biochemistry & Physiology: Open Access

ROS: Dual Nature, Disease, and Therapy.

Abstract

Author(s):

Reactive Oxygen Species (ROS) are fundamental molecules with a dual nature, indispensable for physiological signaling at optimal levels but harmful when excessively produced. Their dysregulation is profoundly implicated in a wide array of human diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions, as well as underpinning inflammatory processes. Moreover, ROS are pivotal in plant physiological functions and immune system responses. Current research actively explores targeted therapeutic strategies, encompassing novel antioxidants and modulators of ROS-generating enzymes, aiming to precisely control ROS levels for broad therapeutic applications and to restore cellular redox balance.