Author(s): Prof. Zhou Wei*
Reactive Oxygen Species (ROS) play a critical dual role in cancer, acting as vital signaling molecules physiologically, yet driving pathological functions when redox balance is skewed. Cancer cells often exhibit elevated ROS but adapt, highlighting the importance of ROS homeostasis. Modulating ROS levels offers promising therapeutic strategies, either by inducing cell death through increased oxidative stress or by repurposing drugs to target ROS metabolism. Understanding ROS’s complex interplay with ferroptosis, Cancer Stem Cells, and the tumor microenvironment is crucial. Ultimately, precise ROS modulation holds significant potential for developing effective, targeted cancer therapies.
