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This collection of reviews explores the pervasive role of oxidative stress across numerous pathologies, including aging, neurodegenerative diseases, cancer, cardiovascular and metabolic syndromes, and chronic kidney disease. It highlights how disrupted cellular processes, like mitochondrial function and inflammation, lead to increased reactive oxygen species, causing cellular damage and disease progression. The papers emphasize understanding these mechanisms for developing targeted interventions and therapeutic strategies, ranging from antioxidant approaches to modulating gut microbiota, to mitigate detrimental effects and improve health outcomes.
