Author(s): Dr. Helena Rodriguez*
Atherosclerosis involves complex lipid metabolic dysregulation at cellular and systemic levels. Macrophage lipid metabolism, contributing to foam cell formation, is critical, alongside the interplay with non-alcoholic fatty liver disease and gut microbiota metabolites. Lipidomic approaches reveal diverse lipid species impacting inflammation and plaque stability. Mitochondrial dysfunction, emerging non-cholesterol lipids, and exosomal lipid cargos further highlight the disease’s multifaceted nature. Adipose tissue and dynamic lipid droplets also play active roles in atherogenesis. Understanding these diverse pathways offers promising targets for therapeutic interventions and personalized risk management, moving beyond cholesterol-centric views
